Random Announcements
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Ha ! Tell me about it man, I woke at 8, then 9, then 10…..then I thought I'd better move my ass.
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^was just thinking the same thing what the fuck are you doing up
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Have you slept yet Mike?
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Ha ha, I bet G appreciates that
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Pretend I'm not a chemist, and tell me what they might be?
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Melatonin is a pineal hormone that plays a central part in regulating bodily rhythms and has been used as a drug to re-align them with the outside world…
...Nine of the ten trials found that melatonin, taken close to the target bedtime at the destination (10pm to midnight), decreased jet-lag from flights crossing five or more time zones. Daily doses of melatonin between 0.5 and 5mg are similarly effective, except that people fall asleep faster and sleep better after 5mg than 0.5mg. Doses above 5mg appear to be no more effective. The relative ineffectiveness of 2mg slow-release melatonin suggests that a short-lived higher peak concentration of melatonin works better. Based on the review, the number needed to treat (NNT) is 2. The benefit is likely to be greater the more time zones are crossed, and less for westward flights. The timing of the melatonin dose is important: if it is taken at the wrong time, early in the day, it is liable to cause sleepiness and delay adaptation to local time. The incidence of other side effects is low. Case reports suggest that people with epilepsy, and patients taking warfarin may come to harm from melatonin.
Random fact: I took part in medical trials for melatonin usage in the 90's, I had to sit in front of giant light lamps and disrupt my sleep cycle; paid quite well.
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Stay safe Ng's.
